DPT Vaccine, Fluid 1987 IAF
Description: Combined D.P.T. Vaccine (Diphtheria Toxoid, Pertussis Vaccine and Tetanus Toxoid combined) is a mixture of pertussis vaccine, purified and concentrated diphtheria and tetanus toxoids. These 2 toxoids are purified and concentrated by a special method, developed in the I.A.-F. laboratories which yields toxoids of high antigenic value.The pertussis component is produced from heat-killed phase 1 strains of Bortadella pertussis and contains the major serogroup antigens 1, 2, and 3.
Indications: Active immunization against diphtheria, pertussis and tetanus. Almost all children of pre-school age are susceptible to diphtheria and whooping cough and it is among these children that the death rate for these two diseases is the highest. Tetanus is a hazard often encountered in childhood.
D.P.T. vaccine should be administered to children as early as possible, by 2 months of age, or at least during the first year of life. A single series of injections ensures active immunity against diphtheria, whooping cough and tetanus. For children who have had whooping cough, or school children, D-40 T-10 vaccine is recommended. Diphtheria Toxoid alone is indicated for immunization against Diphtheria and Tetanus Toxoid alone for immunization against tetanus.
Contraindications: Only healthy children should be vaccinated. Vaccination of febrile children or children with a respiratory infection, a contagious disease of any kind, or even a coryza should be postponed. The vaccination of infants suffering from cyanosis should not be carried out before 8 months of age. Infants suffering from acute eczema, acute dermatitis, cerebral lesions or convulsions should not be vaccinated.
Precautions: A separate sterile syringe and needle or a sterile disposable unit should be used for each patient to prevent transmission of hepatitis B virus or other infectious agents from one person to another.
Adverse Effects: Injection of the vaccine will produce a moderate elevation of temperature. The site of injection becomes slightly tender, swollen or inflamed for a period of 12 to 24 hours. Occasionally the reaction is more marked. A cold water dressing will diminish local reactions.
It may also happen, but infrequently, that after the first injection of D.P.T. vaccine, a child displays allergy to the vaccine. Such a child usually suffers from eczema, hay fever or asthma or is already sensitized to other antigens or has been allergic in the past. Shortly after injection, the child may present decreased pulse, pallor of the teguments, marked perspiration, nausea, diarrhea and a syncopal condition, urticarial plaques appearing at the same time. Adrenaline must be administered immediately. If it is decided to discontinue the injections of the combined D.P.T. vaccine because of the presence of the pertussis component, D-40, T-10 can be used to complete immunization against diphtheria and tetanus.
Note: Unusual reactions occurring concomitantly or following vaccination should always be reported to the manufacturer and to the provincial epidemiologist.
Dosage: To obtain a good immune response, four 1 ml doses of vaccine should be injected s.c., the first 3 doses at intervals of 1 to 2 months, the fourth, 9 to 12 months after the third. Those 4 doses are necessary to ensure good immunity against whooping-cough. It is emphasized that vaccination should be started as early as 2 months of age.
Note: Before administering the second dose of vaccine, inquiries should be made about any reactions observed after the first injection. If after the first injection, the child has had convulsions or any other reactions considered to be contraindications, further injections should be deferred.
Reinforcing Doses: It is strongly recommended that a fifth injection be given during the fifth year of life preferably before entering school. The existing immunity is thus further reinforced.
Withdrawal from an ampul: Shake the ampul to disperse the contents thoroughly immediately before withdrawing the dose of vaccine.
Tap the ampul to ensure that the vaccine is in the lower portion of the ampul rather than the neck.
Using a sterile piece of cotton or sterile towel, break off the top of the ampul at the colored line (no file is required). Then, using an aseptic technique to prevent contamination, and using a sterile needle and syringe, withdraw the contents of the ampul into the syringe, holding the ampul in such a way that the tip of the needle is kept immersed throughout the withdrawal.
Once the ampul has been opened, any of its contents not used immediately should be discarded.
Withdrawal from a vial: Do not remove the rubber stopper from the vial.
Shake the vial to disperse the contents thoroughly immediately before withdrawing a dose of vaccine.
Tear off the central part of the metallic crimp. Moisten the exposed surface of the rubber stopper with a sterile piece of cotton soaked with a suitable antiseptic and allow a few minutes for it to take effect. Draw into a sterile syringe a volume of air equal to the amount of vaccine to be withdrawn from the vial and pierce the centre of the rubber stopper with the sterile needle affixed to the syringe. Invert the vial and slowly inject into it the air contained in the syringe. Keeping the tip of the needle immersed, withdraw into the syringe the required amount of vaccine, then holding the plunger of the syringe steady, withdraw the needle from the vial.
Where multi-doses containers are used, partly used containers should be discarded at the end of a vaccination session to avoid contamination.
The skin at the injection site should be cleaned with a suitable antiseptic and dried with a piece of dry sterile cotton. The vaccine should be injected s.c. preferably on the outer side of the upper arm, near the insertion of the deltoid muscle. It is important to shake the ampul or vial vigorously and obtain a homogeneous suspension immediately before withdrawing the vaccine.
Supplied: Each ml of the combined vaccine contains one dose of: purified diphtheria toxoid 30 Lf units, purified tetanus toxoid 10 Lf units, pertussis vaccine (4 to 12 protective units) contained in 20,000 million bacteria. Scored ampuls of 1 ml, vials of 10 ml. Boxes of 5. Store in refrigerator between 2 to 8°C. Do not freeze. Carefully check the expiry date.
Outdated vaccine should never be used.
Reviewed 1987
DPT Vaccine, Fluid 1985, 1986 IAF (last year produced)
Indications: Active immunization against diphtheria, pertussis, and tetanus. For administration to infants and preschool children only. D.P.T. vaccine should be administered to children as early as possible, by 2 months of age, or at least during the first year of life. A single series of injections ensures active immunity against diphtheria, whooping cough and tetanus. For children who have had whooping cough, or school children, D-40 T-10 vaccine is recommended. Diphtheria Toxoid alone is indicated for immunization against Diphtheria and Tetanus Toxoid alone for immunization against tetanus.
Contraindications: Only children in good health should be vaccinated. Vaccination of febrile children or children with a respiratory infection, a contagious disease or any other kind, or even a coryza should be postponed. The vaccination of infants suffering from cyanosis should not be carried out before 8 months of age. Infants suffering from acute eczema, acute dermitis, cerebral lesions or convulsions should not be vaccinated.
Precautions: A separate sterile syringe and needle or a sterile disposable unit should be used for each patient to prevent transmission of hepatitis B virus or other infectious agents from one person to another.
Adverse Effects: Injection of the vaccine will produce a moderate elevation of temperature. The site of injection becomes slightly tender, swollen or inflamed for a period of 12 to 24 hours. Occasionally the reaction is more marked. A cold water dressing will diminish local reactions.
It may also happen, but infrequently, that after the first injection of D.P.T. vaccine, a child displays allergy to the vaccine. Such a child usually suffers from eczema, hay fever or asthma or is already sensitized to other antigens or has been allergic in the past. Shortly after injection, the child may present decreased pulse, pallor of the teguments, marked perspiration, nausea, diarrhea and a syncopal condition, urticarial plaques appearing at the same time. Adrenaline must be administered immediately. If, for any reason, it is decided to discontinue the injections of the combined D.P.T. vaccine because of the presence of the pertussis component, D-40, T-10 can be used to complete immunization against diphtheria and tetanus.
Note: Unusual reactions occurring concomitantly or following vaccination should always be reported to the manufacturer and to the provincial epidemiologist.
Dosage: Shake the ampul or the vial vigorously and obtain a homogeneous suspension immediately before withdrawing the vaccine. Tap the ampul to ensure that the vaccine is in the lower portion of the ampul rather than in the neck. Once the ampul has been opened, any of its contents not used immediately should be discarded. Where multi-dose containers are used, partly used containers should be discarded at the end of a vaccination session to avoid contamination. To obtain a good immune response, four 1 ml doses of vaccine should be injected s.c., the first 3 doses at intervals of 1 to 2 months, the fourth, 9 to 12 months after the third. Those 4 doses are necessary to ensure good immunity against whooping cough. It is emphasized that vaccination should be started as early as 2 months of age. Note: Before administering the second dose of vaccine, inquiries should be made about any reactions observed after the first injection. If, after the first injection, the child has had convulsions or any other reactions considered to be contraindications, further injections should be deferred.
Reinforcing Doses:It is strongly recommended that a fifth injection be given during the fifth year of life preferably before entering school. The existing immunity is thus further reinforced.
Supplied: Each ml of vaccine contains: purified diphtheria toxoid 30 Lf units, purified tetanus toxoid 10 Lf units and not more than 20 O.U. (20,000 million) killed Phase 1 B. pertussis bacilli. Available in boxes of five 1 ml ampuls and 10 ml multidose vials.
Store in refrigerator between 2 to 8°C. Do not freeze.
Reviewed 1984
DPT Vaccine Fluid 1984 IAF Dosage change
Indications: Active immunization against diphtheria, pertussis, and tetanus. For administration to infants and preschool children only. Contraindications: Only children in good health should be vaccinated. Postpone the vaccination of a child who presents febrile symptoms, who has a respiratory infection, a contagious disease or any other kind, or a coryza. Infants suffering from cyanosis should be vaccinated when they are around 8 months old. A child who has an acute eczema or an acute dermitis, who suffers from cerebral lesions or contusions, or who has had convulsions during the previous 12 months, should not be vaccinated.
Immunization can be started when the child reaches at least 1 year of age, using fractionated and multiple doses. It is suggested to start the injections with a dose of 0.1 mL to determine the degree of sensitivity to the individual, and to gradually increase the dose, according to the response, to reach the ordinary doses. Such immunizations may take from 5 to 8 injections.
Precautions: Proceed with caution when there is evidence of cerebral damage and of previous hypersensitivity reactions. Discontinue vaccination series if severe reactions or convulsions occur.
Adverse Effects: The injection of vaccine gives more local reactions in babies than in older children; this is the contrary to the toxoids alone. The injection will produce a moderate elevation of temperature. The arm may become slightly tender, swollen or inflamed for a period of 12 to 24 hours. Occasionally the reaction is more marked. It is recommended to inject children at the end of the afternoon. Parents will be advised not to give any exercise to the child, to serve him a light supper and to put him in bed early. A cold water dressing will diminish local reactions.
In about 1 case of 100,000 immunizations a child may present with an allergy to the vaccine following the first injection. These are usually children suffering from eczema, hay fever, or asthma or children already sensitized to other antigens. Shortly after injection a decrease of pulse, pallor of the teguments, marked perspiration, nausea, diarrhea, syncope and urticarial plaques may occur. Epinephrine must be administered immediately. If, for any reason, it is decided to discontinue the injections of the combined D.P.T. vaccine one may inject Diphtheria Toxoid alone and Tetanus Toxoid alone or in combination (D-40, T-10 Vaccine). However it is recommended that the degree of sensitivity of the individual to both toxoids be determined.
Dosage: Inject 4 s.c. doses of the vaccine, as follows, 1st dose, 1 ml; 2nd dose, 1 ml; 3rd dose, 1 ml with an interval of 1 to 2 months between each dose and finally a 4th dose of 1 ml between 9 to 12 months after the 3rd dose. All 4 doses are necessary if a strong immunity especially against pertussis is to be obtained. Start vaccination as early as 2 months of age.
Reinforcing dose: 1 ml at 4 to 6 years of age.
Supplied: Each ml of vaccine contains: purified diphtheria toxoid 30 Lf units, purified tetanus toxoid 10 Lf units and not more than 20 O.U. (20,000 million) killed Phase 1 B. pertussis bacilli. Available in boxes of five 1 ml ampuls and 10 ml multidose vials.
DPT Vaccine Fluid 1981(new), 1982, 1983 Institute Armand-Frappier (IAF)
Indications: Active immunization against diphtheria, pertussis, and tetanus. For administration to infants and preschool children only.
Contraindications: Only children in good health should be vaccinated. Postpone the vaccination of a child who presents febrile symptoms, who has a respiratory infection, a contagious disease or any other kind, or a coryza. Infants suffering from cyanosis should be vaccinated when they are around 8 months old. A child who has an acute eczema or an acute dermitis, who suffers from cerebral lesions or contusions, or who has had convulsions during the previous 12 months, should not be vaccinated. Immunization can be started when the child reaches at least 1 year of age, using fractionated and multiple doses. It is suggested to start the injections with a dose of 0.1 mL to determine the degree of sensitivity to the individual, and to gradually increase the dose, according to the response, to reach the ordinary doses. Such immunizations may take from 5 to 8 injections.
Precautions: Proceed with caution when there is evidence of cerebral damage and of previous hypersensitivity reactions. Discontinue vaccination series if severe reactions or convulsions occur.
Adverse Effects: The injection of vaccine gives more local reactions in babies than in older children; this is the contrary to the toxoids alone. The injection will produce a moderate elevation of temperature. The arm may become slightly tender, swollen or inflamed for a period of 12 to 24 hours. Occasionally the reaction is more marked. It is recommended to inject children at the end of the afternoon. Parents will be advised not to give any exercise to the child, to serve him a light supper and to put him in bed early. A cold water dressing will diminish local reactions.
In about 1 case of 100,000 immunizations a child may present with an allergy to the vaccine following the first injection. These are usually children suffering from eczema, hay fever, or asthma or children already sensitized to other antigens. Shortly after injection a decrease of pulse, pallor of the teguments, marked perspiration, nausea, diarrhea, syncope and urticarial plaques may occur.
Epinephrine must be administered immediately. If, for any reason, it is decided to discontinue the injections of the combined D.P.T. vaccine one may inject Diphtheria Toxoid alone and Tetanus Toxoid alone or in combination (D-40, T-10 Vaccine). However it is recommended that the degree of sensitivity of the individual to both toxoids be determined.
Dosage: Inject 4 s.c. doses of the vaccine, as follows, 1st dose: 0.5 ml; 2nd dose, 1 ml; 3rd dose, 1 ml with an interval of 1 to 2 months between each dose and finally a 4th dose of 0.5 ml between 9 to 12 months after the 3rd dose. All 4 doses are necessary if a strong immunity especially against pertussis is to be obtained. Start vaccination as early as 2 months of age. Reinforcing dose: 0.3 to 0.5 ml at 4 to 6 years of age.
Supplied: Each ml of vaccine contains: purified diphtheria toxoid 30 Lf units, purified tetanus toxoid 10 Lf units and not more than 20 O.U. (20,000 million) killed Phase 1 B. pertussis bacilli. Available in boxes of five 1 ml ampuls and 10 ml multidose vials.
| 
